丙型肝炎病毒(HCV)急性感染的患者,大约30%发生自发清除,已经进展为慢性丙型肝炎(CHC)的患者,经过抗病毒治疗,大约40%得到持久的HCV清除.近年来宿主基因变异在HCV感染治疗中的关键作用备受瞩目.今就近期的国内外报道,对白细胞介素(IL)28B的基因变异与HCV感染转归的关系进行综述.%Hepatitis C Virus (HCV) infection is spontaneously resolved in about 30％ of acutely infected individuals.In those who progress to chronic hepatitis, HCV therapy permanently eradicates infection in about 40％ of cases.It has long been suspected that host genetic factors are key determinants for the control of HCV infection.In this study, we will review the relationship between genetic variation in interleukin 28B (IL28B) and the control of HCV infection.
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