Objective To explore antibacterial effect of Shuanghuanglian of Chinese medicine in vitro on acinetobacter baumannii of pan-resistant drugs.Methods Using the broth dilution method,the Shuanghuanglian injection,antimicrobial tests in vitro of Shuanghuanglian in-jection combined with Cefoperazone /sulbactam for the pan-resistant acinetobacter baumannii were conducted .Results Shuanghuanglian MIC for pan - resistant acinetobacter baumannii was 20 mg /mL,effects of Shuanghuanglian combined with Cefoperazone /sulbactam on pan-resistant acinetobacter baumannii greatly reduced compared with single Shuanghuanglian or cefoperazone /sulbactam.Conclusion Shuanghuanglian for pan-resistant acinetobacter baumannii has inhibito-ry effect,the application of traditional Chinese medicine combined with antibiotics can reduce the mount of antibiotics so as to reduce and delay the bacterial resistance.%目的：研究双黄连粉针剂在体外对泛耐药鲍曼不动杆菌的抑菌作用。方法采用肉汤稀释法，在体外进行双黄连粉针剂、双黄连粉针剂联合头孢哌酮/舒巴坦对泛耐药鲍曼不动杆菌的抑菌试验。结果双黄连对泛耐药鲍曼不动杆菌的MIC 为20 mg /mL，双黄连和头孢哌酮/舒巴坦联合作用于泛耐药鲍曼不动杆菌与单用双黄连或头孢哌酮/舒巴坦比较，单独用药的浓度大大降低。结论双黄连对泛耐药鲍曼不动杆菌有抑制作用，中药联合抗生素应用可降低抗生素使用量，以达到减少和延缓细菌耐药的目的。
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