目的 探讨血清肿瘤标志物甲胎蛋白(AFP)、癌胚抗原(CEA)、糖类抗原199(CA199)联合检测在消化系统恶性肿瘤诊断中的临床价值.方法 回顾性分析203例因消化系统疾病住院的患者,经内镜、病理及腹部CT确诊,其中消化系统恶性肿瘤125例,消化系统良性疾病78例,均应用化学发光法检测血清AFP、CEA和CA199的水平.结果 恶性肿瘤患者AFP、CEA、CA199均高于良性消化疾病患者,差异有统计学意义(P<0.05或P<0.01).AFP、CEA与CA199联合检测较单项检测对消化系统恶性肿瘤诊断的敏感度更高.结论 血清肿瘤标志物AFP、CEA和CA199检测作为诊断性试验,在消化道恶性肿瘤的诊断中具有重要的价值,而联合检测使敏感度得到明显提高,降低了消化道肿瘤的漏诊率.%Objective To evaluate and discuss the clinical value of combined detection of serum tumor makers AFP, CEA and CA199 in several diagnosed malignancies of digestive system.Methods The single and combined detecting results of AFP, CEA, CA199 in 203 patients with digestive tract diseases were retrospectively analyzed. Seventy - eight patients with benign diseases and 125 patients with malignant tumors were diagnosed by endoscopy, pathology and abdominal CT. Results The patients with malignant tumors had higher levels of AFP, CEA and CA199 that of the patients with benign diseases(P＜0.05 or P＜0.01). The combined detection of AFP, CEA and CA199 made the sensitivity increased. Conclusion Serum tumor markers AFP, CEA and CA199 are of an important value as a diagnostic test for malignant tumors in digestive system. The combined detection can improve the sensitivity and reduce the rate of missed diagnosis of gastrointestinal cancer.
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