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CLINICAL VALUES OF COMBINED HEPATOMA-SPECIFIC AFP FRACTION AND AFP-mRNA DETERMINATION IN DIAGNOSIS AND DIFFERENTIATION OF HEPATOCELLULAR CARCINOMA

机译:肝细胞特异性AFP馏分结合AFP-mRNA测定在肝细胞癌诊断和鉴别诊断中的临床价值

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Hepatocellular carcinoma (HCC) is one of the most common malignant tumors worldwide. HOC prognosis is poor and early detection is of the utmost importance. Although serum alpha-fetoprotein (AFP) is a useful tumor marker for the detection and monitoring of HCC development, the false-negative or false-positive rate with AFP level alone may be as high as 30 % - 40 % for patients with small size HCC. To enhance the specificity and accuracy of AFP for HCC diagnosis, we analyzed AFP expression statues in liver tissues, detected serum hepatoma-specific ALP fraction CALP-L3) and AFP-mRNA from peripheral blood mononuclear cells (PBMCs), and explored their clinical implications for HCC diagnosis.
机译:肝细胞癌(HCC)是全球最常见的恶性肿瘤之一。 HOC预后很差,早期发现至关重要。尽管血清甲胎蛋白(AFP)是检测和监测HCC发育的有用肿瘤标志物,但小剂量患者仅凭AFP水平的假阴性或假阳性率可能高达30%-40%肝癌为了提高AFP在HCC诊断中的特异性和准确性,我们分析了肝组织中AFP的表达状态,检测了外周血单核细胞(PBMC)的血清肝癌特异性ALP组分CALP-L3)和AFP-mRNA,并探讨了其临床意义用于HCC诊断。

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