Objective To observe the curative effects of anticoagulant therapy with Argatroban in treating acute cerebral infarction within 48 h after onset.Methods Patients with acute cerebral infarction within 48 h after onset from Janurary 2014 to October 2015 were collected and divided according to whether Argatroban used or not.Patients received Argatroban therapy was in experimental group,and the other patients were in control group.NIHSS scores were measured before and after treatment and at 14 d of the course of disease.And mRS scores were measured at 6 months of the course of disease.The curative effects of the two groups were compared.Results There was 155 patients at this study,with experimental group of 107 cases and control group of 48 cases.There was no significant difference in age,sex,admission blood pressure,NIHSS scores and so on between the two groups.The improve value of NIHSS score in experimental group was significantly higher than that in control group (P<0.05).The mRS score in experimental group was significantly lower than that in control group (P<0.05).In control group,the NIHSS score at 14 d of the course of disease was significantly lower than at peak (P<0.05).In experimental group,the NIHSS score at 14 d of the course of disease was significantly lower than at peak and at admission (all P<0.05).Conclusion The curative effect and prognosis of anticoagulant therapy with Argatroban in treating acute cerebral infarction within 48 h after onset is very good.%目的 观察阿加曲班抗凝治疗发病48 h内的急性脑梗死的疗效.方法 收集2014 年1月~2015年10月我院神经内科收治的发病48 h内的急性脑梗死患者.根据是否使用阿加曲班治疗分组,使用阿加曲班的患者入试验组,未使用阿加曲班的患者入对照组.在治疗前、后及病程14 d时进行NIHSS评分,病程6个月时进行mRS评分.比较两组疗效.结果 本研究共计入组155例患者,试验组107例,对照组48例.两组患者年龄、性别、入院时血压、NIHSS评分等差异均无统计学意义.试验组NIHSS评分改善值明显高于对照组,6个月时mRS评分明显低于对照组(均P<0.05).对照组病程14 d时NIHSS评分明显低于NIHSS评分峰值,试验组病程14 d时NIHSS评分明显低于入院时NIHSS评分和NIHSS评分峰值(均P<0.05).结论 发病48 h内的急性脑梗死患者采用阿加曲班抗凝治疗疗效和预后较好.
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