目的 探究普拉洛芬联合玻璃酸钠对白内障超声乳化吸除人工晶状体(IOL)植入术后患者泪液氧化应激指标及血管内皮生长因子(VEGF)水平的影响.方法 选取2014年12月至2016年6月收入我院行白内障超声乳化术后出现眼干不适并诊断为干眼者76例(106只眼),依据随机数字表法分成观察组和对照组,每组53只眼.对照组仅给予玻璃酸钠治疗,观察组在对照组基础上给予普拉洛芬治疗,对两组患者的眼表、泪膜功能、泪液氧化应激指标和VEGF进行比较.结果 术前两组角膜荧光素染色(FL)、泪膜破裂时间(BUT)和泪液分泌(SIt)等指标比较均无显著差异(P >0.05),治疗后FL显著降低(P <0.05),BUT、SIt显著升高(P <0.05),且观察组术后3、7、30 d相比于对照组FL降低更显著,BUT、SIt上升更显著,差异比较具有统计学意义(P <0.05);两组治疗前丙二醛(MDA)、超氧化物歧化酶(SOD)、过氧化脂质(LPO)和总抗氧化能力(TAC)比较均无显著差异(P >0.05),治疗后两组患者各指标均得到显著改善,且观察组治疗后MDA、LPO显著低于对照组,SOD、TAC指标明显高于对照组,差异具有统计学意义(P <0.05);两组治疗前房水VEGF水平比较无显著性差异(P >0.05),治疗后两组的房水VEGF水平显著低于治疗前,且观察组房水VEGF水平显著低于对照组,差异具有统计学意义(P <0.05).结论 普拉洛芬联合玻璃酸钠对白内障超声乳化吸除IOL植入术后干眼疗效优于单用玻璃酸钠,能有效改善患者的临床症状和氧化应激指标,降低VEGF水平.%Objective To explore the effects of pranoprofen and sodium hyaluronate on tear oxidative stress index and VEGF level in patients after phacoemulsification and IOL implantation.Methods 106 eyes with dry eye after cataract phacoemulsification were selected from our hospital between December 2014 and June 2016.Patients were randomly divided into observation group and control group,53 eyes in each group.The control group was treated with sodium hyaluronate and the observation group were given pranoprofen in addition.Ocular surface, tear film function, oxidative stress and VEGF levels were compared between the 2 groups.Results There was no significant difference in FL,BUT and SIt between the two groups before the surgery(P >0.05).After surgery,FL was significantly reduced(P <0.05)and BUT and SIt sig-nificantly increased(P <0.05)in both groups,and compared to the control group,FL in the observation group decreased more significantly and BUT and Sit increased significantly at 3d,7d,30d significantly(P <0.05).Before treatment, there were no significant difference between the two groups in MDA,SOD,LPO and TAC.After treatment,all these bio-markers significantly improved in both groups.MDA and LOP were significantly lower,and SOD and TAC were significant-ly higher in observation group than in control group(P <0.05).There is no significant difference in the anterior chamber aqueous VEGF level between the two groups before treatment.VEGF was significantly lower in observation group than in control group(P <0.05).Conclusions The effects of pranoprofen and sodium hyaluronate on the treatment of dry eye in patients after phacoemulsification and IOL implantation is better than sodium hyaluronate alone.Pranoprofen can effectively improve the patient's clinical symptoms and indicators of oxidative stress,and decrease VEGF level.
展开▼
