目的：探讨微创经椎间孔腰椎间融合术( MIS-TLIF)治疗腰椎退变性疾病的可行性和早期疗效。方法采用MIS-TLIF治疗30例腰椎退变性疾病患者，其中Ⅰ~Ⅱ度退行性或峡部裂型腰椎滑脱症12例，退行性腰椎管狭窄伴节段性不稳8例，腰椎间盘突出症10例。均为单节段融合。结果手术时间127~209(168±41) min；术中出血量23~361(192±169) ml；术中X线照射时间72~136(104±32) s；术后首次下床活动时间1．4~3．8(2．6±1．2) d。疼痛VAS评分术前(7．20±1．02)分，末次随访(1．71±0．66)分，差异有统计学意义(P<0．01)。末次随访椎间融合率为100%。未发生并发症。 X线片显示cage无移位、松动、下沉，椎弓根钉无松动、折断。结论 MIS-TLIF对腰椎的解剖结构破坏小，对椎旁肌肉的剥离少，患者术后恢复快，是一种有效、安全、损伤较小的手术方法，可用于腰椎不稳、局限节段椎间盘病变、≤Ⅱ度以下腰椎滑脱的患者；但手术时间较长，医患X线暴露较多。%Objective To investigate the feasibility and early curative effect of minimally invasive transforaminal lum-bar interbody fusion ( MIS-TLIF) in the treatment of low lumbar degenerative disease. Methods A total of 30 pa-tients underwent MIS-TLIF for low lumbar degenerative disease. They contained 12 cases ofⅠ~Ⅱdegree spondylo-listhesis,8 cases of degenerative lumbar spinal stenosis with segmental instability and 10 cases of protrusion of lumbar intervertebral disc. All the patients underwent one-level fusion by the same surgeon. Results The surgical time, in-traoperative blood loss volume, X-ray exposed time and the first leaving bed time after surgery were 127~209(168 ± 41) min, 23~361(192 ± 169) ml, 72~136(104 ± 32) s,1. 4~3. 8(2. 6 ± 1. 2) d. VAS of the preoperative and the last follow-up were (7. 20 ± 1. 02)points and (1. 71 ± 0. 66)points,the difference had statistical significance(P<0. 01). The rates of fusion and complication incidence were 100% and 0% at the last follow-up. The X-ray film showed that the cage in intervertebral space was in good position and pedicle screws had not any displacement or snap. Conclusions MIS-TLIF is appropriate for Ⅰ~Ⅱ degree spondylolisthesis, degenerative lumbar spinal steno-sis and protrusion of lumbar intervertebral disc and has an advantage of less blood loss and trauma. But it takes more time to finish the operation and X-ray exposing time is more.
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