Objective:To investigate the osteoporosis status (OP) and its risk factors in long-term hospitalized schizophrenic patients.Method:The bone mineral density was measured in 555 inpatients with schizophrenia,and then they were divided into OP group and non-OP group based on the result of the measurement.The general demographic and clinical data in the two groups were compared and the main factors affecting bone density were analyzed.Results:The incidence of OP in 555 schizophrenic patients with long-term hospitalization was 67.7％ (376 cases).In the OP group the ratio of female and the age were significantly higher than those in the non-OP group(P ＜0.05 or P ＜0.01);BMI of male was significantly lower than fale of the non-0P group(P ＜0.01);the age and blood glucose levels of female were significantly higher than those in female of the non-OP group (all P ＜0.01).Multivariate logistic regression analysis showed that in male patients the incidence of OP was decreased with the increase of BMI (P ＜ 0.01);the incidence of OP in female patients was increased with the increase of age (P ＜ 0.05).Conclusion:Long-term hospitalized schizophrenia patients present higher risk of OP;Low BMI in male patients and age in famale patinets are risk factors for OP of schizophrenic patients.%目的:探讨长期住院精神分裂症患者骨质疏松(OP)状况及其危险因素. 方法:对555例长期住院的精神分裂症患者进行骨密度测定,并据此分为OP组(376例)及非OP组(179例);比较两组一般人口学资料及临床资料,分析影响骨密度的主要因素. 结果:555例长期住院的精神分裂症患者中OP发生率为67.7％(376例);与非OP组比较,OP组女性患者的比例及患者年龄显著增高(P＜0.05或P＜0.01);其中OP组男性患者体质量指数(BMI)明显低于非OP组男性(P＜0.01);女性患者年龄及血糖水平明显高于非OP组女性(P均＜0.01);多因素Logistic回归分析显示男性患者随着BMI值增高,OP发生率减低(P＜0.01);女性患者随着年龄的增加OP发生率增加(P＜0.05). 结论:长期住院的精神分裂症患者OP风险较高;低BMI和高龄分别是男性及女性精神分裂症患者OP危险因素.
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