Objective To evaluate the prognostic value of pentraxin-3 in patients with refractory mycoplasma pneumonia. Methods 166 children with mycoplasma pneumonia were divided into the RMPP group ( n=66 ) and the MPP group ( n=100 ) . The level of PTX-3 was measured during acute and recovery phase. ROC analysis was used to evaluate the prognostic value of PTX3 to RMPP. Relation analysis and univariateregression analysis were used to evaluate the relation between PTX3 and RMPP. Results The levels of PTX-3 in the RMPP group was higher than that in the MPP group during acute phase. It showed high VAP diagnostic value by ROC analysis. When the level of PTX-3 was more than 47. 7 ng/ml, the sensitivity and specificity were 78% and 87% respectively. The level of PTX-3 showed a positive correlation with RMPP. Conclusion PTX-3 is an novel and promising bio-marker of RMPP di-agnosis.%目的：探讨难治性支原体肺炎( RMPP)患儿血清穿透素3水平改变及临床意义。方法我院住院治疗的支原体肺炎患儿166例,分为RMPP组( n=66)和MPP组( n=100)。观察急性期和恢复期血清PTX3水平改变。利用受试者工作特征曲线( ROC)分析PTX3水平对RMPP患者疾病诊断的价值。利用约登指数分析最佳切点PTX3数值。应用Pearson和Speaman线性相关和单因素回归分析PTX3与RMPP的关系。结果在RMPP和MPP患儿急性期血清PTX3和CRP水平明显高于对照组( P<0．05)。 RMPP组患儿血清PTX3水平明显高于MPP患者(P<0．05)。重症肺炎组和非重症肺炎组患儿急性期血清PTX3和CRP水平明显高于对照组(P<0．05)。重症肺炎组患儿血清PTX3水平明显高于非重症肺炎组患儿(P<0．05)。通过Pearson和Speaman相关性分析后发现,PTX3水平与RMPP呈正相关(r=0．417,P=0．015)。对RMPP的诊断价值方面,PTX3表现出中等诊断价值, AUC为0．762(P=0．011)。结果发现PTX3(是否大于47．7)(OR=3．33,95% CI 1．94-6．45,P<0．05)为RMPP发生的独立因素。结论 RMPP患者血清PTX3水平明显升高,是诊断RMPP的潜在生物学标记物。
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