目的：探讨呼出气一氧化氮( FeNO)在老年哮喘-慢性阻塞性肺疾病重叠综合征( ACOS)患者中的变化情况。方法对我院在2013年10月~2015年3月收治的42例老年ACOS患者进行FeNO测定,并与同期收治的42例慢性阻塞性肺疾病(简称慢阻肺)、35例哮喘及42例非呼吸系统疾病老年患者进行对比研究。结果(1)老年ACOS组FeNO的检测结果为(48．6±13．9)ppb,显著高于非呼吸系统疾病组[(21．5±11．8)ppb]和慢阻肺组[(34．7±13．4)ppb](均P<0．01),而显著低于哮喘组[(61．5±15．1)ppb](P<0．01)。(2)以27 ppb为切点,则治疗前FeNO的增高率,ACOS组(83．3%)显著高于慢阻肺组(52．4%)和非呼吸系统疾病组(21．4%)(均P<0．01),而与哮喘组(88．6%)无显著差异(P>0．05)。结论 FeNO在老年ACOS患者中显著增高,FeNO测定对老年患者气道炎症的评估具有很好的作用。%Objective To investigate the measurement of fractional exhaled nitric oxide ( FeNO) in elderly patients with asthma-chronic obstructive pulmonary disease overlap syndrome (ACOS). Methods FeNO test was applied for 42 elderly patients with ACOS before treatment. Another 42 patients with chronic obstructive pulmonary disease ( COPD) , 35 patients with asthma and 42 patients without respiratory diseases were taken as control groups. Results (1) Before treatment, the level of FeNO in the ACOS group was (48. 6 ± 13. 9) ppb, which was higher than in the non-respiratory disease group [(21. 5 ± 11. 8)ppb] and the COPD group [(34. 7 ± 13. 4)ppb] (P<0. 01, respectively), but lower than in the asthma group [(61. 5 ± 15. 1)ppb] (P<0. 01). (2) Taking 27 ppb as cut-off value of FeNO, the increased rate of FeNO (≥27 ppb) in the ACOS group (83. 3%) was significantly higher than that in the COPD group (52. 4%) and the non-respiratory disease group (21. 4%) (P<0. 01, respectively), while it had no significant difference with the asthma group ( 88. 6%) ( P>0. 05 ) . Conclusion FeNO is signifi-cantly higher in elderly ACOS patients, and its determination has a good effect to assess airway inflammation in elder-ly patients.
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