目的：探讨抗生素序贯疗法联合转移因子治疗儿童急性下呼吸道感染疗效和安全性。方法174例急性下呼吸道感染儿童患者，随机分为观察组和对照组，每组87例。对照组给予阿奇霉素序贯治疗（常规治疗＋阿奇霉素注射液3 d；再给予常规治疗＋阿奇霉素片5 d），观察组在对照组的基础上加服转移因子4周。对两组患者治疗疗效、症状改善时间、细胞免疫功能、不良反应进行观察。结果观察组治疗总有效率为95.4％，显著高于对照组的86.2％（P＜0.05）；观察组退热时间、咳嗽消失时间为（2.39±0.57）天、（4.73±1.56）天，均显著低于对照组的（3.59±0.5）天、（6.35±1.89）天（P＜0.05）；治疗后观察组患者CD3＋、CD4＋和CD4＋／CD8＋分别为（62.09±12.29）％、（46.38±10.12）％和（1.72±0.76），显著高于对照组的（57.38±9.46）％、（42.43±9.69）％和（1.45±0.67），（P＜0.05）；观察组不良反为3.5％，低于对照组的4.6％（P＞0.05）。结论抗生素序贯疗法联合转移因子治疗儿童急性下呼吸道感染疗效显著，提高儿童免疫力。%Objective To investigate the efficacy and safety of sequential antibiotic therapy combined with transfer factor therapy in the treatment of children with acute lower respiratory tract infection.Methods 1 74 children with acute lower respiratory tract infection were randomly divided into the observation group and the control group,87 cases in each group.The control group was given azithromycin sequential therapy (conventional therapy +azithromy-cin injection,3d;and then conventional therapy +azithromycin tablets,5d),and the observation group was given transfer factor therapy (4 weeks)based on the control group.Their efficacy,symptoms improved time,immune func-tion,and adverse reactions of the two groups were observed.Results The total effective rate of the observation group was 95.4%,which was significantly higher than that of the control group (86.2%,P<0.05).The time of fever re-lieving and cough disappear in the observation group were (2.39 ±0.57)days and (4.73 ±1.56)days respectively, which were significantly lower than those in the control group [(3.59 ±0.5)days and (6.35 ±1.89)days](P<0.05 ).After the treatment,the levels of CD3+,CD4+and CD4+/CD8+in the observation group were (62.09 ± 1 2.29)%,(46.38 ±1 0.1 2)% and (1.72 ±0.76)respectively,which were significantly higher than those in the control group [(57.38 ±9.46)%,(42.43 ±9.69)%and (1.45 ±0.67)],(P<0.05).The incidence of adverse reactions in the observation group was 3.5%,which was lower than that in the control group (4.6%,P>0.05). Conclusion Sequential antibiotic therapy combined with transfer factor therapy can effectively improve the immunity in the treatment of children with acute lower respiratory infections.
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