Objective To explore a genetic relationship between the polymorphism of microsatellites vWA and D 5S818 with schizophrenia .Methods DNA samples collected from patients with schizophrenia ( n=57 ) and random population ( n=123 ) were amplified by PE Profiler plus system for multiplex PCR .Then ABI 3130-Avent genetic analyzer was used for automatic capillary electrophoresis and genotyping .Results The detection ratios of vWA -14 were 21.9%and 33.3%in schizophrenia group and control group , respectively .The difference was statistically significant between the two groups (P<0.05).While there was no significant difference in the frequency of D 5S818 between the groups (P>0.05).No de-viations from the Hardy-Weinberg equilibrium were observed .Conclusion There is a strong association of vWA -14 with schizophrenia , suggesting a possible linkage between vWA -14 and some schizophrenia resistant genes .There may be genes on chromosome 12 associated with susceptibility to schizophrenia .%目的：探讨微卫星vWA和D5 S818的多态性与精神分裂症有关的易感基因区域。方法对57例精神分裂症患者（精神分裂症组）和123名随机人群（对照组）采用PE Profiler plus系统进行PCR复合扩增，然后用ABI公司的310型基因分析仪自动进行电泳分离和基因检测。结果精神分裂症组的vWA-14的检出率为21．9％，对照组检出率为33．3％，两者之间差异有显著性意义（P＜0．05）；D5S818位点的各等位基因频率的检出率两组之间差异无显著性意义（ P＞0．05）。经吻合度检验，2个微卫星各等位基因频率的分布，均符合Hardy-Weinberg平衡。结论 vWA-14位点与精神分裂症有明显关联，提示vWA-14可能与精神分裂症某种抵抗基因连锁，表明在第12号染色体上存在与精神分裂症相关的基因。
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