A20是炎症信号传导的中心调节因子-NF-κB抑制因子,而近年研究发现A20更重要的功能是作为一个肿瘤抑制因子,其缺失在淋巴细胞肿瘤的发生中有重要的作用.综述近年所报道的A20生物学功能、分子机制及其在淋巴细胞肿瘤中调节作用的研究进展.%A20 was originally identified as a key regulator of inflammation signalling pathways, a NF-κB inhibitor.Recently, A20 has also been proposed to function as a tumor suppressor.Lacking A20 is involved in tumorigenesis in several human B-cell lymphomas.In this review, current knowledge concerning the feature of A20 biological activities, as well as the underlying molecular mechanisms, and the regulating role of A20 in lymphocytic malignancies is summarized.
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