目的 通过比较听力正常者40 Hz听觉相关电位(40 Hz auditory event related potential,40 Hz AERP)、短纯音脑干听觉诱发电位(tone burst auditory brainstem response,Tb-ABR)、听性稳态反应(auditory steady-state response,ASSR)3种频率特异性听觉诱发电位(auditory evoked potential,AEP)的反应阈与纯音测听(pure tone audiometry,PTA)闽值之间的差异及相关性. 方法 对34例(68耳)正常听力者进行言语频率(0.5、1、2、4 kHz)的PTA及3种频率特异性AEP测试,比较3种AEP与PTA阈值之间的关系,并对其进行相关性分析.结果 3种频率特异性AEP反应阈在言语频率与PTA阈值之间都存在良好的相关性,但在各频率与PTA阈值之间的差值存在不同的差异性.在0.5kHz频率,40Hz AERP与PTA阈值之间的差值最小,且相关性最好；在1kHz频率,ASSR、40Hz AERP与PTA阈值之间的差值相近,差异无统计学意义,但40Hz AERP相关性好于ASSR;而在2、4kHz频率,ASSR与PTA阈值之间差值均最小,且相关性最好.结论 在需要准确评估行为听阈时,不同频率的行为阈值可选用不同的检测方法,从而提高听阈评估的准确性.%Objective To provide supports for the application of auditory evoked potential(AEP) in the evaluation of behavioral threshold, by studying the difference and relevance between the pure tone audiometry (PTA) and three frequency-specific auditory evoked potentials, including 40 Hz auditory event related potentials (40 Hz AERP), tone burst auditory brainstem response(Tb-ABR) and auditory steady-state response (ASSR). Methods Three frequency-specific AEP and PTA thresholds were recorded at speech frequency (0.5, 1, 2, 4kHz) from thirty-four adults with normal hearing (68 ears). Then, the relationship between the AEP thresholds and PTA thresholds were analyzed respectively. Results There were good correlations between three frequency-specific AEP thresholds and PTA thresholds at speech frequency. However, the difference of thresholds between each frequency-specific AEP and PTA was not same. The difference of thresholds were the smallest and the relevance were the best between 40 Hz AERP and PTA at 0.5 kHz, and between ASSR and PTA at 2, 4 kHz. At 1 kHz, there were not statistical difference between ASSR, 40 Hz AERP and PTA, while the relevance of 40 Hz AERP was better than ASSR. Conclusion Different methods should be chosen to assess the objective behavioral thresholds at different frequency.
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