目的：制备格列本脲片，筛选出最佳处方工艺。方法：采用均匀设计法，以硬度，溶出度为指标，优化处方。结果：格列本脲片优化处方为微晶纤维素65mg，甘露醇12mg，低取代羟丙纤维素4mg，硬脂酸镁0.3mg，硬度约4Kgf，溶出度95%以上。结论：该处方合理，工艺简单，质量稳定。%Objective:To prepare Glibenclamide Tablets,and to optimize the formula technology. Methods:The formula was optimized by uniform design using dissolution and hardness as index,Results:The optimal formula of Glibenclamide tablets was as folowed:microcrystaline celulose,mannitol,L-HPC,magnesium Stearate were 65mg,12mg,4mg,0.3mg.The values of dissolution 3 batches of samples were more than 95%,and hardness was about 4Kgf.Conclusion: The formula of glibenclamide tablets is reasonable, technology is simple, quality is stable.
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