近年来,二维层状纳米材料在生物医学领域引起研究人员的广泛关注.然而,这些二维层状纳米材料所具备的生物学性质尚未被完全探明,其相应的生物学应用仍有很大的局限性.联合使用超声和溶剂热剥离的方法对二硫化钼(MoS2)和二硫化钨(WS2)粉末进行处理,成功制备小尺寸二维层状纳米材料 MoS2和 WS2.通过抗坏血酸催化氧化实验,首次制备得到的二维层状纳米材料 MoS2和 WS2均具有类氧化酶活性,并且纳米MoS2的类氧化酶活性高于纳米 WS2.进一步实验表明两种层状纳米材料均能够氧化抗氧化生物分子-谷胱甘肽,对革兰氏阴性菌(大肠杆菌)和阳性菌(金黄色葡萄球菌)均表现出有效的抗菌活性.此外,发现 MoS2的抗菌活性高于 WS2,这与两者的类氧化酶活性一致.%Graphene-like two-dimensional layered nanomaterials have recently drawn great attention in the field of biomedicine.However,the biological properties and applications of these 2D nanomaterials have not been fully understood.In this paper,the small-sized 2D layered nanomaterials including MoS2 and WS2 were prepared by using the combination of sonication and solvothermal treatment of bulk MoS2 and WS2 powder.The experi-ments of ascorbic acid catalytic oxidation demonstrate that the fabricated nanomaterials possess oxidase-like ac-tivity and MoS2 exhibits stronger activity than WS2.Further experiment shows the MoS2 and WS2 nanomaterials can cause the oxidation of glutathione,thereby exhibiting antimicrobial activity against both gram-negative and gram-positive bacteria.And the MoS2 shows more efficient antimicrobial activity than WS2,which is in accord-ance with the activity of oxidases.In this work,theoretical guidance for the research and application of the 2D layered nanomaterials as potential enzyme mimics were provided.
展开▼
