Objective:To investigate the value of white blood cell (WBC) count and the levels of procalcitonin (PCT),C-reactive protein (CRP) and interleukin-6 (IL-6) in the evaluation of the disease severity in elderly patients with pulmonary infection.Methods:56 elderly patients with pulmonary infection in our hospital from September 2015 to September 2016 were selected and divide into common infection group (29 cases) and severe infection group (27 cases) according to the severity of infection.They were also divided into groups with better outcome (43 cases) or death group (13 cases) in accordance with the prognosis of disease.21 elderly non-infection patients were also selected as a control group.The WBC count and PCT,CRP and IL-6 levels were detected,and the value of them for evaluation of disease severity was analyzed.Results:The WBC count and PCT,CRP and IL-6 levels in the common and severe infection group were higher than those in the control group,and were highest in the severe infection group (P＜0.05).The WBC count and PCT,CRP and IL-6 levels of patients in prognosis dead group were higher than those with better outcome.The combination detection of WBC,PCT,CRP and IL-6 has much higher sensitivity and specificity,compared with single tests each (P＜0.05).PCT and IL-6 detection showed the highest and lowest sensitivity and specificity,respectively.Conclusion:WBC,PCT,CRP,and IL-6 were benefit for the diagnosis of pulmonary infected in elderly patients.The combination detection was valuable for assessing the severity of the disease.%目的:通过检测长期卧床老年肺部感染患者白细胞(WBC)、降钙素原(PCT)、C反应蛋白(CRP)以及白介素6(IL-6)的水平,探讨这些指标在长期卧床老年肺部感染患者病情评估中的价值.方法:选取2015年9月至2016年9月安徽省合肥市滨湖医院收治的56例长期卧床肺部感染老年患者,根据感染严重程度分为普通感染组(29例)及重症感染组(27例),根据转归情况分为预后好转组(43例)及预后死亡组(13例),同期选取本院收治的21例长期卧床未发生感染的老年患者作为对照组;检测各组患者WBC、PCT、CRP及IL 6的水平,并分析WBC、PCT、CRP及IL 6对病情的评估价值.结果:普通感染组患者PCT、CRP、WBC及IL-6水平显著高于对照组,但显著低于重症感染组患者,组间比较差异均有统计学意义(均P＜0.05).预后死亡组患者PCT、CRP、WBC及IL-6水平显著高于预后好转组患者,差异均有统计学意义(均P＜0.05).4项联合检测敏感及特异度明显高于其他各单项检测(P＜0.05);单项检测中,PCT敏感度和特异性最高,IL-6敏感度和特异性最低.结论:WBC、PCT、CRP及IL-6联合检测能够为长期卧床老年肺部感染患者的诊断提供有利信息,联合检测对评估病情具有重要参考价值.
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