Objective:to investigate the effect of preoperative paclitaxel + cisplatin neoadjuvant chemotherapy on the proliferation and invasion of cancer cells in esophageal cancer.Methods:106 patients with esophageal cancer who underwent radical operation for esophageal cancer in our hospital between September 2014 and March 2017 were divided into the neoadju-vant chemotherapy group(n= 54,receiving preoperative paclitaxel + cisplatin neoadjuvant chemotherapy)and the normal group(n=52,receiving no preoperative neoadjuvant chemotherapy)according the therapeutic regimen.The differences in the expression of proliferation genes and invasion genes in the postoperative lesion tissue specimens were compared between the two groups.Results:The proliferation genes MACC1,Nucleostemin,TRAF4 and USP39 mRNA expression in lesion tissue of neo-adjuvant chemotherapy group were lower than those in lesion tissue of normal group whereas DEC 1,PTPN14,KLF4 and LATS1 mRNA expression were higher than those in lesion tissue of normal group;invasion genes EphA2,MACC1,MMP-9, PFN2,Snail and SphK1 mRNA expression in lesion tissue of neoadjuvant chemotherapy group were lower than those in lesion tissue of normal group whereas PTEN and RACK1 mRNA expression were higher than those in lesion tissue of normal group. Conclusion:The paclitaxel + cisplatin neoadjuvant chemotherapy before esophageal cancer surgery can effectively inhibit the proliferation and invasion activity of esophageal cancer cells.%目的:探讨术前紫杉醇+顺铂新辅助化疗对食管癌病灶内癌细胞增殖、侵袭的影响.方法:选择2014年9月~2017年3月在本院接受食管癌根治术治疗的食管癌患者106例,回顾治疗方案并将上述患者分为新辅助化疗组(n=54,术前接受紫杉醇+顺铂新辅助化疗)、常规组(n=52,术前未经新辅助化疗).对比两组患者术后所得病灶组织标本中增殖基因、侵袭基因表达量的差异.结果:新辅助化疗组病灶组织中增殖基因MACC1、Nucleostemin、TRAF4、USP39 mRNA的表达量低于常规组病灶组织(P<0.05),DEC1、PTPN14、KLF4、LATS1 mRNA的表达量高于常规组病灶组织(P<0.05);新辅助化疗组病灶组织中侵袭基因EphA2、MACC1、MMP-9、PFN2、Snail、SphK1 mRNA的表达量低于常规组病灶组织(P<0.05),PTEN、RACK1 mRNA的表达量高于常规组病灶组织(P<0.05).结论:食管癌术前接受紫杉醇+顺铂新辅助化疗,可有效抑制食管癌细胞的增殖及侵袭活性.
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