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首页> 外国专利> Cellular model of the human ovary cancer in a culture with poclitaxel induced reverse poclitaxel and cisplatin resistance and the application of that model

Cellular model of the human ovary cancer in a culture with poclitaxel induced reverse poclitaxel and cisplatin resistance and the application of that model

机译：紫杉醇诱导的逆性紫杉醇和顺铂耐药性培养的人卵巢癌细胞模型及其应用

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the object of the application is the human ovarian cancer cell line.ptx resistant and sensitive to cddp (human ovarian cancer cell line with the reverse resistance to ptx and cddp) derived from the parent a2780, characterized by that,that shows the most elevated expression of at least two genes selected from the group consisting of genes aard, gnai1,plk2 and slc30a8 and the most reduced expression of at least five genes selected from the group consisting of genes gpm6a, has2, nrxn1, rcan1, rspo2,tes and zic1 compared to the parent cell line a2780.the declaration also contains way of human ovarian cancer cell line with the reverse resistance to ptx and cddp,a cell line treated with increasing concentrations of treatment stages ptx and application of human ovarian cancer cells showing reverse resistance to ptx and cddp to research the working mechanismnew anti-cancer medicines or treatments.in addition, the subject of are genes selected from the group including abcb1, dnaja1p5, emc10, olfm3, timp1, trib2, tes, rhobtb1, glul, pfkp, s100a11, sox4, cdkn2a, stk26, aard, gnai1, plk2,slc30a8, spock2, gpm6a, has2, nrxn1, ntng1, rcan1, rspo2, zic1, tpbg, grip1 and nmi for use as markers of reverse resistance to ptx and cddp in cell lines of human ovarian cancer.
机译：本申请的目的是从母体a2780衍生的对ddp具有抗性并且对cddp（对ptx和cddp具有反向抗性的人卵巢癌细胞系）具有抗性和敏感性的ptx，其特征在于，其显示最高的表达选自基因aard，gnai1，plk2和slc30a8的至少两个基因，以及选自基因gpm6a，has2，nrxn1，rcan1，rspo2，tes和zic1的至少五个基因表达降低最多该声明还包含对ptx和cddp具有反向耐药性的人卵巢癌细胞株的方法，经治疗浓度不断升高的ptx治疗的细胞株以及对人卵巢癌细胞具有ptx反向耐药性的应用和cddp研究新的抗癌药或治疗药物的工作机制。此外，的主题选自abcb1，dnaja1p5，emc10，ol fm3，timp1，trib2，tes，rhobbtb1，glul，pfkp，s100a11，sox4，cdkn2a，stk26，aard，gnai1，plk2，slc30a8，spock2，gpm6a，has2，nrxn1，ntng1，rcan1，rcanb，tcan1，tcan1， nmi用作人类卵巢癌细胞系中对ptx和cddp的反向耐药性的标志物。

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