Objective:To explore the effect of dialectical behavior therapy on the serum neurotransmitters and cytokines in depression patients with suicidal tendency.Methods:Total of 98 depression patients with suicidal tendency who were treated in the hospital between August 2014 and August 2017 were collected and divided into the control group(n=49)and the re-search group(n=49)by random number table.Control group received routine drug therapy,and study group received dialecti-cal behavior therapy combined with drug therapy.The differences in serum levels of monoamine neurotransmitters,nerve func-tion indexes and acute phase proteins were compared between the two groups of patients.Results:After treatment,serum NE, 5-HT and DA levels of research group were higher than those of control group;serum MBP and NSE levels of research group were lower than those of control group while BDNF level was higher than that of control group;serum Tf level of research group was higher than that of control group while Hp level was lower than that of control group.Conclusions:Dialectical be-havior therapy intervention can effectively optimize the nerve function and improve the overall state of depression patients with suicidal tendency.%目的:探讨辩证行为疗法对于有自杀倾向抑郁症患者血清神经递质、细胞因子的影响.方法:收集2014年8月~2017年8月间本院收治的自杀倾向抑郁症患者98例,经随机数表法分为对照组及研究组各49例.对照组患者接受常规药物治疗,研究组患者接受辩证行为疗法合并药物治疗.对比两组患者血清中单胺类神经递质、神经功能指标、急性反应蛋白含量的差异,结果:治疗后,研究组患者血清中NE、5-HT、DA的含量高于对照组患者;研究组患者血清中MBP、NSE的含量低于对照组患者,BD-NF的含量高于对照组患者研究组患者血清中 Tf的含量高于对照组患者,Hp的含量低于对照组患者.结论:自杀倾向抑郁症患者接受辩证行为疗法干预,可有效优化患者神经功能、改善整体状态.
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