目的：：观察前列地尔脂微球载体制剂静滴联合生肌膏外敷在褥疮愈合中的作用.方法：对2013年1月~2015年1月于我院治疗的 III、IV 级褥疮100例患者病历资料进行回顾分析,入选患者依据治疗方案不同分为观察组及对照组,各50例,2组患者血糖、感染、血压均有效控制.观察组患者采用前列地尔脂微球载体制剂静脉滴注联合生肌膏外敷治疗,对照组患者采用川芎嗪注射液静脉滴注联合生肌膏外敷治疗；2组患者均以治疗4周为1个疗程.于治疗后1,2,3,4周取褥疮创面标本,采用 SABC法显影观察毛细血管密度值(/10 HP),并测量开次给药后褥疮创面周围1 cm 经皮氧分压值(TcPO 2)及创面表皮温度变化.结果：观察组治疗1,2,3,4周时褥疮创面毛细血管密度均明显多于对照组(P ＜0．05),观察组给药2,4,6,8h 后褥疮创面皮肤温度均明显低于同期对照组(P ＜0．05),而褥疮创面 Tc-PO 2均明显高于同期对照组(P ＜0．05).结论：前列地尔脂微球载体制剂联合生肌膏可有效改善褥疮创面血液循环,促进褥疮创面愈合.%Objective:To observe the effect of lipidmicrosphere prostaglandin (Lipo PGE1)combined with Shengji plas-ter on the bedsore healing.Methods:A total of 100 patients with bedsores in III and IV degree who were admitted in our hospi-tal from January,2013 to January,201 5 were included in the study and divided into the observation group and the control group with 50 cases in each group according to different treatment protocols.The blood glucose,infection,and blood pressure in the two groups were effectively controlled.The patients in the observation group were given intravenous drip of Lipo PGE1 and external application of Shengji plaster,while the patients in the control group were given intravenous drip of Chuanxiongqin injection and external application of Shengji plaster.Four-week treatment was regarded as one course.The specimens on the wound surface of bedsores 1,2,3,and 4 weeks after treatment were collected.SABC developing method was used to observe the blood capillary density value (/10 HP).TcPO 2 1 cm around the wound surface and the skin temperature were measured. Results:The blood capillary density values 1,2,3,and 4 weeks after treatment in the observation group were significantly higher than those in the control group (P <0.05).The bedsore wound surface skin temperature 2,4,6,and 8 h after medica-tion in the observation group was significantly lower than that in the control group (P <0.05),while TcPO 2 was significantly higher than that in the control group (P <0.05).Conclusions:Lipo PGE1 combined with Shengji plaster can effectively improve the blood circulation on the wound surface of bedsores,and promote the bedsore healing.
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