Objective To investigate the relationships of blood pressure variability ( BPV ), heart rate variability ( HRV ) and left ventricular hypertrophy in patients with hypertension. Methods In 86 patients with hypertension and 42 healthy people, ambulatory blood pressure monitoring, dynamic electrocardiogram and ultrasound cardiograph were recorded and analyzed. Results The average systolic blood pressure at different time, systolic blood pressure standard deviation of 24 hours and day time were of significant difference between the two hypertension groups and control group; at the same time, average blood pressure and their standard deviation at different time of the left ventricular hypertrophy group ( group A2 ) were significantly higher than those of pure hypertension group ( group Al ) and the control group ( group B ). Left ventricular mass index of group A2 were positively correlated with systolic blood pressure standard deviation at different time. Compared with group B, heart rate variability index of the two hypertension groups decreased; moreover, that of group A2 reduced significantly higher than those of group Al and group B. Conclusion Autonomic nervous system function is damaged in patients with hypertension, while the autonomic nervous disorders are aggravated when combined with left ventricular hypertrophy.%目的 探讨高血压患者血压变异性、心率变异性与左心室肥厚之间的关系.方法 选择高血压患者86例及健康者42例进行动态血压、动态心电图监测及心脏彩超测定.结果 两高血压组与对照组比较,其不同时段平均收缩压、24h收缩压标准差及日间收缩压标准差差异有统计学意义(P＜0.05);同时左心室肥厚组(A2)不同时段平均血压及其标准差显著高于单纯高血压组(A1)及对照组(B).A2组左心室质量指数与不同时段平均收缩压标准差呈正相关.两高血压组与B组比较,心率变异指数降低;A2组减低程度明显高于A1组及B组.结论 高血压患者存在机体自主神经功能受损,而合并有左心室肥厚者可加重自主神经功能紊乱.
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