Objective To evaluate the influence of the 204A ＞ C polymorphism of CYP7A1 gene on the GSD and serum lipid levels.Methods According to inclusion/exclusion criteria,eligible studies on CYP7A1 gene-204A C polymorphism of serum lipid levels and the risk of GSD were retrieved.Depending on the between-study heterogeneity,the fixed-or random-effects model was applied,and the data were analyzed using the RevMan software.Results Five studies totaling 830 GSD patients and 882 healthy controls were used to evaluate the relation of CYP7A1-204A C polymorphism with GSD.Overall comparison of alleles A with C in all study population yielded 5％ but non-significant increased risk of GSD (OR =1.05,95％ CI:0.91 ～ 1.22,P =0.48).Subgroup analysis by ethnic differences did not show any association between CYP7A1-204AC polymorphism and GSD either.Four studies totaling 802 cases and 691 controls were used to assess the relation of CYP7A1-204A C polymorphism with serum lipid levels.All the subjects were from the Asian population.The pooled effects indicated that AC genotype had higher levels of TG than AA (MD =-0.42,95％ CI:-0.76 ～ 0.08,P =0.01).CC genotype in cases had higher levels of TC (M D =0.65,95％ CI:0.25 ～ 1.05,P =0.001) and LDL-C (MD=0.40,95％ CI:0.06～0.73,P=0.02) thanAA,AA(MD=-0.35,95％ CI:-0.60～0.10,P=0.007) andAC (MD =0.35,95％ CI:-0.61 ～0.08,P =0.01) genotypes in controls had higher levels of TC than CC,and AA genotype in controls had higher levels of HDL-C than CC(MD =-0.15,95％ CI:-0.21 ～-0.09,P ＜ 0.00001).Conclusions The CYP7A1-204A C polymorphism is significantly associated with serum lipid levels in Asian population,but not gallbladder stone disease.%目的 评价CYP7A1-204A/C基因多态性与胆石病风险及血清脂质水平之间的相关性.方法 通过纳入排除标准,获取符合要求的文献;根据研究间的异质性,确定使用随机效应模型或固定效应模型,使用RevMan对数据进行分析.结果 使用5篇文献评估CYP7A1-204A/C基因多态性与胆石病风险间的关系,涉及病例组人群830名,对照组健康人群882名.结果显示,CYP7A1-204A等位基因导致GSD风险提高5％(OR=1.05,95％ CI:0.91～1.22,P=0.48),提高幅度不显著.以种族进行的亚组分析后,仍未见显著差异.使用4篇文献对CYP7A1-204A与血清脂质水平的相关性进行分析,涉及病例组人群802名,健康对照组人群691名.所有对象均为亚洲人.数据整合结果显示,AC基因型比AA基因型人群TG水平更高,差异显著(MD=-0.42,95％ CI=-0.76 ～0.08,P=0.01).显示AC基因型比AA基因型人群TG水平更高,差异显著(MD=-0.42,95％ CI=-0.76～0.08,P =0.01).CC基因型病例组人群的LDL-C显著高于AA基因型病例组人群(MD=-0.40,95％ CI =0.06 ～0.73,P=0.02);AA基因型比CC基因型对照组人群有着更高的TC水平(MD=-0.35,95％ CI=-0.60～0.10,P=0.007);AC基因型对照组人群的TG水平高于CC基因型对照组人群,差异显著(MD=-0.35,95％ CI=-0.61～-0.08,P=0.01);对比对照组人群的CC基因型,AA基因型人群的HDL-C水平更高(MD=-0.15,95％ CI=-0.21～ 0.09,P=0.0000098).结论 CYP7 A1-204A/C多态性与GSD风险在亚洲人群中无相关性;但是,CYP7A1-204A/C多态性与血清脂质水平有显著相关性.
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