Genetic Polymorphisms Analysis of Glutathione S-transferase M1 and T1 in Children with Acute Lymphoblastic Leukemia

王军; 张利; 冯建飞; 王宏; 朱绍先; 胡豫; 李玉香

首页> 中文期刊> 《当代医学科学(英文)》 >Genetic Polymorphisms Analysis of Glutathione S-transferase M1 and T1 in Children with Acute Lymphoblastic Leukemia

Genetic Polymorphisms Analysis of Glutathione S-transferase M1 and T1 in Children with Acute Lymphoblastic Leukemia

开具论文收录证明 >>

期刊封面封底目录下载 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Summary: The relationship between glutathione S-transferases (GSTs) M1, T1 genotype and childhood acute lymphoblastic leukemia (ALL) was investigated. GSTM1 and GSTT1 genotypes in genomic DNA from 67 children with ALL and 146 healthy controls were analyzed by using the multiplex polymerase chain reaction (PCR). The frequencies of GSTM1, M1-T1 null genotypes in ALL children were significantly higher than in the healthy controls (76.12 % versus 52.74 %, OR=2.856, P0.05). It was suggested that GSTM1 null genotype might be a risk genotype of childhood ALL, while there as no correlation between GSTT1 null genotype and childhood ALL.

著录项

来源
《当代医学科学(英文)》 |2004年第3期|243-244|共2页
作者
王军; 张利; 冯建飞; 王宏; 朱绍先; 胡豫; 李玉香;
展开▼
作者单位

Department of Hematology;

Union Hospital;

Tongji Medical College;

Huazhong University of Science and Technology;

Wuhan 430030;

China;

Department of Pediatrics;

The Third Affiliated Hospital;

Zhengzhou University;

Zhengzhou 450052;

China;

Department of Pediatrics;

The Third Affiliated Hospital;

Zhengzhou University;

Zhengzhou 450052;

China;

展开▼
原文格式 PDF
正文语种 chi
中图分类急性白血病;
关键词
遗传多态性; 谷胱甘肽; S-转移酶; M1; T1; 急性淋巴细胞白血病; 基因型;

相似文献

中文文献
外文文献
专利

Genetic Polymorphisms Analysis of Glutathione S-transferase M1 and T1 in Children with Acute Lymphoblastic Leukemia

摘要

著录项

相似文献

相关主题

期刊订阅