目的:探究前列地尔对高原型心脏病合并心功能不全患者血气指标和NT-proBNP的影响.方法:选择2014年3月~2017年3月我院接诊的70例高原型心脏病合并心功能不全的患者进行研究.按照随机数表法,随机均分为观察组和对照组.对照组予以吸氧平喘、维持电解质平衡等常规治疗,观察组在常规治疗的基础上联合前列地尔,分析比较两组患者治疗前后动脉血氧分压(PaO2)、动脉血二氧化碳分压(PaCO2)、动脉血氧饱和度(SaO2)、N末端脑钠肽前体(NT-proBNP)的变化情况及不良反应的发生情况.结果:与治疗前相比,观察组患者血气指标均有明显改善;治疗后,观察组患者指标明显优于对照组;治疗后14天,观察患者血浆NT-proBNP水平为(556.38 ±102.53)ng/L,对照组为(1247.49±210.68)ng/L,两组患者血浆NT-proBNP显著下降,且观察组NT-proBNP水平明显低于对照组,差异均有统计学意义;观察组不良反应发生率为8.57%,对照组为11.43%,两组不良反应发生情况无显著性差异.结论:前列地尔能够有效改善高原性心脏病合并心功能不全患者的血气指标,降低血浆NT-proBNP浓度,增强患者心功能,纠正缺氧状态,是一种安全高效的治疗方法,值得推广应用.%Objective To explore the effects of Alprostadil on the blood gas index and Nt-proBNP in patients with high al-titude heart disease with heart failure. Methods 70 cases of high altitude heart disease with heart failure patients from March 2014 to March 2017 in our hospital were studied. According to the random table method, 70 cases patients were randomly di-vided into observation group and control group. The control group was treated routinely including oxygen, calm asthma, maintain the electrolyte balance and the observation group was combined with Alprostadil on the basis of routine treatment, the arterial partial pressure of oxygen (PaO2), arterial partial pressure of carbon dioxide (PaCO2), arterial oxygen saturation (SaO2), N-terminal pro brain natriuretic peptide (NT-proBNP), and the adverse reaction of the two groups were recorded. Results After the treat-ment, blood gas index were significantly improved in the observation group compared with before treatment, the blood gas index of the observation group were significantly better than the control group.14 days after treatment, the NT-proBNP in the observa-tion group was (556.38±102.53) ng/L and (1247.49±210.68) ng/L in the control group. Plasma NT-proBNP was significantly reduced in both groups, and the NT-proBNP in the observation group was significantly better than that in the control group, all the differences were statistically significant. The incidence of adverse reactions was 8.57% in the observation group and 11.43% in the control group, there was no significant difference between the two groups of adverse reactions. Conclusion Alprostadil can effectively improve the blood gas index of patients with high altitude heart disease and heart failure, decrease plasma NT-proBNP, enhance the patient's cardiac function and correct hypoxia. It is a safe and efficient treatment, and worthy of clinical application.
展开▼
