目的:研究慢乙肝基础上药物性肝损伤的临床表现、实验室指标的特点.方法 :采用回顾性分析的方法,收集2012年1月~2014年12月期间在我院诊断为药物性肝损伤患者一般资料、肝功能、凝血酶原时间等,根据乙肝表面抗原检测(HBsAg)分为乙肝阳性组和乙肝阴性组(下文均简写为阳性组、阴性组),阳性组38例,阴性组55例.根据不同资料类型进行统计学分析.结果 :93例药物性肝损伤患者中,阴性组和阳性组DILI临床分型均以肝细胞损伤型为主,ALT、黄疸较阴性组高,阳性组发病年龄低于阴性组;阳性组重型肝炎发病率高于阴性组患者;凝血酶原时间、AST、ALP、TB、CB等比较均无明显差异.结论 :慢乙肝基础上的药物性肝损伤对肝脏损伤更重.%Objective To study the clinical features of drug-induced liver injury in patients with chronic hepatitis B and the characteristics of laboratory indexes. Methods By retrospective analysis method, from January 2012 -2014 year in Decem-ber in our hospital diagnosed as patients with drug-induced liver injury data, liver function, prothrombin time, according to the detection of hepatitis B surface antigen (HBsAg) were divided into positive group and negative group of hepatitis B hepatitis B (hereinafter abbreviated as positive group and negative group). Positive group 38 cases, 55 cases of negative group. Statistical analysis was performed according to different data types. Results 93 cases of drug-induced liver injury in patients with negative group and positive group DILI clinical type in hepatocellular damage type, ALT, jaundice was higher than the negative group , positive group age lower than the negative group; positive group than in negative group the incidence of severe hepatitis patients;prothrombin time, AST, ALP, TB and CB showed no obvious differences. Conclusion Drug induced liver injury on the basis of chronic hepatitis B is more important to liver damage.
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