目的 观察钩芍降压方对慢性肾脏病并老年高血压病患者的影响.方法 将124名老年慢性肾脏病并高血压病患者随机分为治疗组和对照组,两组均给予硝苯地平控释片治疗,治疗组加用钩芍降压方;动态血压监测仪记录治疗前后血压数值及变异性的变化,同时比较肾小球滤过率(GFR).结果 治疗后两组患者血压均有下降,治疗组较对照组下降明显,差异具有统计学意义(P<0.05);两组患者治疗结束后24小时血压变异率均有所下降,治疗组较对照组下降明显,差异具有统计学意义(P<0.05);治疗后两组GFR均有提高,治疗组较对照组提高,差异无统计学意义(P>0.05).结论 钩芍降压方对慢性肾脏病并老年高血压病患者的血压、血压变异性均有积极影响.%Objective To observe the effects of Goushao Jiangya prescription on chronic kidney disease combined with hypertension in aged patients. Methods 124 aged patients of chronic kidney disease combined with hypertension were divided into two groups randomly. Both groups were given nifedipine controlled release tablets, Goushao Jiangya prescription was added in treatment group. Blood pressure was detected with ambulatory blood pressure monitor before and after treatment in both groups. Glomerular filtration rate (GFR) was also detected in both groups. Results Blood pressure in both groups decreased after treatment. And the blood pressure in treatment group decreased significantly compared with that in control group, the difference was statistically significant (P<0.05). The blood pressure variety ratio was decreased in both groups 24 h after treatment, and the blood pressure variety ratio in treatment group decreased more significantly than that in control group, and the difference was statistically significant (P<0.05). After treatment, GFR was improved in both groups, and the GFR was higher in treatment group than that in control group, but the difference was not significant (P>0.05). Conclusion Goudhao Jianyya prescription shows positive effects on blood pressure, blood pressure variety ratio in aged patients of chronic kidney disease with hypertension.
展开▼
