The electrocatalytic oxidation behaviors and electrochemical kinetics of salbutamol ( SAL) were investigated at sodium dodecyl benzenesulfonate ( SDBS) self-assembled monolayers and 1 -ben-zyl-3-methylimidazole hexafluorophosphate ([ BnMIM ] PF6 ) modified carbon paste electrode ( SDBS -[BnMIM] PF6/CPE). The experimental results indicated that the SDBS - [BnMIM] PF6/CPE showed an excellent electrocatalytic activity toward SAL. The electrochemical kinetic parameters were determined by cyclic voltammetry ( CV ) and chronoamperometry ( CA ) at SDBS - [ BnMIM ] PF6/ CPE. The catalytic oxidation peak current of SAL versus its concentration had a good linear relationship in the concentration range of 9. 0 ×10 -5 - 1. 0 × 10 -3 mol·L-1 and the detection limit ( S/N = 3) was 1. 08 × 10-6 mol· L-1 by square wave voltammetric( SWV) method. The proposed method was successfully applied in the electrochemical quantitative determination of SAL content in commercial inhaled salbutamol solution.%研究了沙丁胺醇(SAL)在表面活性剂十二烷基苯磺酸钠(SDBS)现场自组装膜与离子液体1-苄基-3-甲基咪唑六氟磷酸盐([ BnMIM] PF6)复合修饰碳糊电极(SDBS -[ BnMIM] PF6/CPE)上的电催化氧化行为和电化学动力学性质.实验结果表明,SDBS -[ BnMIM] PF6/CPE对SAL的电化学氧化具有良好的催化作用.用循环伏安法(CV)和计时电流法(CA)测得SAL在SDBS -[ BnMIM] PF6/CPE上的电极反应过程动力学参数.用方波伏安法(SWV)测得SAL氧化峰电流(Ips)与其浓度在9.0×10-5～1.0×10-3mol·L-1范围内呈良好的线性关系,检出限(S/N=3)为1.08 ×10-6 mol·L-1.运用该方法对市售吸入用沙丁胺醇溶液中SAL的含量进行了测定,结果满意.
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