类风湿性关节炎(Rheumatoid Arthritis，RA)是一种以多发性、对称性关节炎症为主，可引起肢体严重畸形的慢性全身性自身免疫性疾病，其发病机制目前尚不完全明确。文章从与类风湿性关节炎发生发展相关的免疫细胞(包括CD4+T细胞、B细胞、先天性免疫细胞)、细胞因子以及微小RNA等方面对该病发病机制的有关研究进展进行综述。%Rheumatoid arthritis (RA) is a chronic, systemic inlfammatory and autoimmune disorder that primarily affects joints. The pathogenesis of RA is not completely understood yet. In this review, the research progress of the immunologic mechanisms in the pathogenesis of RA was summarized.
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