宫颈癌是妇科肿瘤中的第二大常见肿瘤,现已明确人乳头瘤病毒(HPV)感染是宫颈癌的主要致病因素,但并非所有HPV感染都会导致官颈癌.HPV L1蛋白是HPV的主要衣壳蛋白,其表达与HPV的复制及其早期感染密切相关.近年研究表明,在目前细胞学基础上检测病变组织HPV L1蛋白可提高官颈病变筛查及预测病变进展的准确度,预防官颈病变的过度诊治.综述HPV L1在预测官颈病变的发展及预后的科学性及实用性,以寻找更加合理的筛查流程,对不同患者选择不同的治疗方案.%Cervical cancer is the second most common tumor in gynecologic oncology,HPV L1 protein is the major capsid protein of HPV,and it's expression is closely related to viral replication and early infection. Recent study shows that present screening method simultaneously unites HPV L1 capsid protein detection may enhances the accuracy for the screening cervical disease and prediction of progression of lesions. This review is concentrated on update scientific nature and the usability of the research for detection of HPV L1 capsid protein in predicting the prognosis and development of cervical disease a review, looking for the more reasonable screening flow, and choosing the different therapeutic schedule for different patients.
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