近年,无论在经济发达的国家或是边远落后地区,早产发生率均有上升趋势.早产儿死亡占新生儿死亡的45.9%-75%,存活的早产儿中8%-25%留有神经及智力方面的后遗症.早产的原因尚未阐明,但内在炎症反应是其主要病因.多种病原体可导致宫内感染,促进基质金属蛋白酶(MMPs)在成纤维细胞内快速表达,分解细胞外基质和调节氨基酸葡聚糖,刺激羊膜、蜕膜和绒毛膜产生前列腺素,从而促使胎膜早破、宫颈成熟和扩张、子宫收缩乃至胎盘剥离,导致早产的发生.%In recent years, premature delivery has an ascending trend in whatever developed countries or poorer areas. Premature infants is 45.9％ 75％ of neonates mortality, while 8％ 25％ survived infants have nerve and intelligence sequelae. The etiology of preterm labor and deliver is still not clear. Internal inflammation reaction may be its leading pathogeny. Manifold pathogen cause infection in uterine cavity, promote matrix metalloproteinases express rapidly in fibroblasts. MMPs decompose the extracellular matrix and regulate glycosamine, thus stimulates amnion,decidua and chorion to produce prostaglandin(PG). PG can result in the preterm premature rupture of the membranes,the cervical ripening and dilation, uterine contraction and placenta abruption. At the end, premature delivery is unavoidable.
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