Objective:To explore the effects of anxiety disorder on the clinical outcomes of in-vitro fertilization-embryo transfer (IVF-ET).Methods:The anxiety level was assessed and analyzed by the Hamilton anxiety scale (HAMA) for 210 patients undergoing IVF-ET treatment.They were then divided into three groups:the A group (mild anxiety,n=55),the B group (moderate anxiety,n=105),and the C group (severe anxiety,n=50).Several parameters of the three groups,including the number of retrieved oocyte,2PN rate,the rate of highqualified embryo,clinical pregnant rate and early abortion rate,were compared.Results:The retrieved oocyte number,2PN rate,the rate of high-qualified embryos and clinical pregnant rate in the A group were significantly higher than those in the B group and the C group (P＜0.05).The clinical pregnancy rate in the B group was significantly higher than that in the C group (P＜0.05).Conclusions:The heavier the anxiety,the worse the effect on the outcome of IVF-ET.The anxiety level should be evaluated in IVF patients if possible,and treated with appropriate psychological intervention in those patients with moderate and severe anxiety,so as to improve their outcomes of IVF-ET.%目的:探讨不同程度焦虑障碍对体外受精-胚胎移植(IVF-ET)后妊娠结局的影响.方法:采用汉密尔顿焦虑量表(HAMA)对210例行IVF-ET的女性患者进行焦虑程度测评及分析,根据患者焦虑程度分为3组,A组55例,轻度焦虑;B组105例,中度焦虑;C组50例,重度焦虑.比较分析各组获卵数、2原核(2PN)受精率、优质胚胎率、周期取消率、临床妊娠率及早期流产率等.结果:A组患者的获卵数、2PN受精率、优质胚胎率和临床妊娠率均显著高于B组及C组,差异有统计学意义(均P＜ 0.05);B组患者临床妊娠率显著高于C组,差异有统计学意义(P＜0.05).结论:随着焦虑障碍程度的加重,其对IVF-ET结局产生的不良影响也加重,应高度重视患者的焦虑程度,进行恰当的心理干预及治疗以改善IVF-ET妊娠结局.
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