Objective To investigate the stability of 1% lauromacrogol foam sclerosant prepared with different liquid-to-air ratio in order to find out the optimal liquid-to-air ratio. Methods According to Tessari technique, two 10 ml disposable plastic syringes and one three-way plastic stopcock were used to mix 1%lauromacrogol with room air, and liquid-to-air ratios from 1∶1 to 1∶9 were separately employed to make the preparation of the foam sclerosant. Each kind of liquid-to-air ratio was used to separately make bubbles for 5 times, the foam half-life time (FHT), the foam drainage time (FDT) and the foam coalescence time (FCT) were recorded, and their mean values were calculated. The optimal liquid-to-air ratio was defined as the intermediate values of all the above measured indexes. Results When the liquid-to-air ratio was 1 ∶ 1, 1 ∶2, 1 ∶ 3, 1 ∶ 4, 1 ∶ 5, 1 ∶ 6, 1 ∶ 7, 1 ∶ 8 and 1 ∶ 9, the FHT of 1% lauromacrogol foam sclerosant was 184.8, 169.3, 135.9, 110.8, 111.5, 92.6, 76.3, 74.7 and 49.9 seconds respectively; the FDT was 10.6, 17.8, 14.6, 13.7, 13.0, 12.3, 10.7, 11.5 and 12.6 seconds respectively; while the FCT was 108.4, 79.8, 41.8, 20.3, 10.4, 0, 0, 0 and 0 seconds respectively. Conclusion Based on Tessari technique, the indoor air, two 10 ml disposable plastic syringes and one three-way plastic stopcock are used to prepare 1%lauromacrogol foam sclerosant, and the optimal liquid-to-air ratio is 1 ∶ 2.%目的：观察以不同液-气比制作1%聚桂醇泡沫的稳定性，明确最佳液-气比。方法根据Tessari法，采用1%聚桂醇注射液、室内空气、2个10 ml一次性塑料注射器和1个医用硅胶三通旋塞阀分别以1∶1、1∶2、1∶3、1∶4、1∶5、1∶6、1∶7、1∶8、1∶9液-气比制作泡沫硬化剂。每种液-气比分别制作泡沫5次，记录泡沫半衰期（FHT）、泡沫析水时间（FDT）和泡沫融合时间（FCT）并计算其均值。最佳液-气比定义为上述所有测量指标的中间值。结果液-气比为1∶1、1∶2、1∶3、1∶4、1∶5、1∶6、1∶7、1∶8、1∶9时，1%聚桂醇泡沫的FHT分别为184.8、169.3、135.9、110.8、111.5、92.6、76.3、74.7、49.9 s，FDT分别为10.6、17.8、14.6、13.7、13.0、12.3、10.7、11.5、12.6 s，FCT 分别为108.4、79.8、41.8、20.3、10.4、0、0、0、0 s。结论采用室内空气、10 ml一次性塑料注射器和医用硅胶三通旋塞阀、以Tessari法制作1%聚桂醇泡沫时的最佳液-气比为1∶2。
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