Objective:To investigate the effect of the BmK-9-(2) on the sodium current in guinea-pigventricular myocytes. Methods:The whole cell patch-clamp technique was used. Results:The BmK-9-(2)increased the magnitude of the peak inward sodium current (27 %) ,peak sodium conductace (17 %) and theprolong time course of sodium channel inactivation (8%) and there was no effects on calcium channels.Conclusion:BmK-9-(2) can activate sodium channel and prolong the inactivated course of myocytes.%目的:观察东亚钳蝎毒BmK-9-(2)对豚鼠心室肌细胞钠通道的作用。方法:采用全细胞膜片钳方法。结果:BmK-9-(2)使钠通道峰值电流增加27%。峰值钠电导增加17%。钠通道未失活成分增加8%。BmK-9-(2)对心肌细胞钙通道没有明显影响。结论:BmK-9-(2)可激活钠通道并使钠通道失活过程延长。
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