The research of matrine which is the main components of leguminous plant sophora is paid great at-tention by relevant scientific research institutions and personnel for its diversial biological activities. The biolog-ical activities and applications of matrine derivatives is reviewed. The research on its synthetic and derivatiza-tion synthesis is emphatically introduced,and its applications and future development trend is prospected.%苦参碱作为豆科植物苦参的主要成分，因其生物活性多样，其研究受到相关科研机构和人员的极大关注。本文就苦参碱及其衍生物的生物活性和合成研究进行了综述，重点介绍了其全合成和衍生化方面的合成研究，并对其今后发展应用趋势进行了展望。
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