Objective To determine the intracutaneous concentration of Ftibamzone given percutaneously to test animals and investigate its percutaneous penetrability and the intracutaneous drug level. Methods An HPLC method combined with homogeneization was used to determine the intracutaneous concentration of Ftibamzone after topical administration. Results The percutaneous absorption and penetrability of Ftibamzone was relatively low. Conclusion The results of the test can give reference to the study of dermatopharmacoki-netics of Ftibamzone in human.%目的 测定试验动物皮肤给药后的皮内药物浓度,观察受试制剂的经皮渗透及进入皮肤的药物水平.方法 试验乳猪局部外用酞丁胺软膏后,采用匀浆法结合高效液相色谱测定皮内药物浓度.结果 酞丁安软膏外用于皮肤后,有一定量的经皮吸收和渗透,但是吸收量相对较低.结论 本试验结果可为酞丁安人体皮肤药代动力学研究提供参考.
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