目的 采用系统评价的方法探讨DNA修复基因X线修复交叉互补因子3(x- ray cross - complementing group 3,XRCC3) 18067C＞T位点单核苷酸多态性与头颈部肿瘤易感性的关系.方法 检索PubMed(1966～2010年)、EMBASE( 1974～2010年)、中国生物医学文献数据库CBM(1978～2010年)、中国期刊全文数据库CNKI(1994～2010年)公开发表的关于DNA修复基因XRCC3 - 18067C＞T单核苷酸多态性与头颈部肿瘤易感性的研究.病例组及对照组XRCC3 - 18067C＞T等位基因分布的比值比( odds ratio,OR)为效应指标,根据一致性检验的结果,选择固定效应模型或随机效应模型对OR进行合并,并进行偏倚评估.结果 共查到符合要求的文献9篇,病例组1872例,对照组3521例.分析结果显示:XRCC3 - 18067C ＞T位点突变纯合子(T/T)患头颈部肿瘤的风险与野生型纯合子(C/C)相比OR=L.16(95％ CI:0.95 ～ 1.43,P=0.150)；隐性模式下,18067C＞T位点突变纯合子(T/T)患头颈部肿瘤的风险与野生型(纯合子+杂合子)(C/C)+(C/T)相比OR=1.16(95％ CI:0.96～1.40,P=0.124)；显性模式下,18067C＞T位点突变个体(突变纯合子+突变杂合子)(T/T)+(C/T)患头颈部肿瘤的风险与野生型纯合子(C/C)相比OR=1.05(95％ CI:0.93～1.19,P=0.426).结论 DNA修复基因XRCC3 18067C＞T位点单核苷酸多态性与头颈部肿瘤易感性间存不在明显相关性.%Objective To evaluate the relationship between X - ray cross - complementing group 3 ( XRCC3 ) gene single neucleotide polymorphisms and head and neck cancer susceptibility. Methods By searching Medline, EMBSE, CBM and CNKI.et al, we collected studies about DNA X - ray cross - complementing group 3 ( XRCC3) gene polymorphisms and head and neck cancer susceptibility. The odds ratios (OR) of variant allele of XRCC3 - 18067C >T was calculated by using statistic software STATAU.O. Publication bias was also evaluated. Results Nine case -control studies were identified for the systematic review. A total of 1872 cases and 3521 controls were included. In the (T/T)VS(C/C) group, the odds ratio was 1. 16(95% CI:0.95 - 1.43, P =0. 150). For the recessive genetic model, in the (T/T)VS(C/C) +(C/T) group,the odds ratio was 1. 16(95% CI:0. 96 -1.40,P=0. 124). For the dominint genetic model, in the (T/T) +(C/T)VS(C/C) group,the odds ratio was 1.05(95% CI:0. 93 - 1. 19 ,P =0. 426). Conclusion There was no close relationship between DNA repaire gene X - ray cross - complementing group 3 ( XRCC3) single neucleotide polymorphisms and head and neck cancer susceptibility.
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