Bio-leaching is one of effective methods for low-grade ores mining. It has profound significance for highly efficient utilization of non-renewable resources. It has been many reports revolving around effecting factors and envi-ronment parameters in the bio-leaching process. However,the systemization of the effecting factors,environment pa-rameters as well as the mathematical models of the bio-leaching process were rarely induced and summarized. Firstly, the effecting factors and environment parameters of bio-leaching were dilated;secondly,based on mechanism of leac-hing,the mathematical models of the effecting factors and environment parameters were dealt with;finally,an outlook on the predictability,controllability,and optimization design of mining production were put forward in this paper.%生物浸矿是贫矿采集的有效方法之一，对不可再生资源的高效利用有着深远的意义。围绕生物浸出过程的影响因素和环境参数有很多的研究报道，但是系统化的对生物浸出过程的影响因素与环境参数及其数学模型鲜有归纳总结。详述生物浸出的影响因素与环境参数，在浸出机理的基础上论述了影响因素与环境参数的数学模型，并对采矿生产的可预测性、可控制性和最优化设计提出展望。
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