目的：探讨结肠癌组织中肿瘤坏死程度与结肠癌临床病理学特征和预后之间的关系。方法：对132例 HE 染色的结肠癌病理组织切片标本评估肿瘤坏死程度，分析肿瘤坏死程度和临床病理学特征及预后之间的关系。结果：肿瘤坏死程度与有无淋巴结转移（P =0.037）和临床分期显著相关（P =0.037），与性别、年龄、肿瘤侵袭深度、远处转移、组织学类型、组织学分级无关。单因素生存分析显示肿瘤坏死面积小于整个肿瘤面积10%的患者较大于和等于10%的患者总生存期明显延长（P =0.014）。多因素分析结果表明肿瘤坏死程度是结肠癌患者总生存时间独立的预后因素（HR =2.162，95% CI =1.032~4.531，P =0.041）。结论：肿瘤坏死可能参与结肠癌的发展，是结肠癌病人独立的预后因素。%Objective:To analyze the tumor necrosis and to determine its association with the clinicopathological characteristics and prognosis of patients with colon cancer. Methods:The extent of tumor necrosis was assessed on 132 H and E stained colon cancer histopathologic slides,the association of tumor necrosis and clinicopathological characteristics and prognosis was analyzed. Results:Extent of necrosis was significantly associated with presence of lymph node metastases(P = 0. 037)and clinical stage(P = 0. 037),but was unrelated to gender,age,deeper inva-sion,distant metastasis,histology type and grade. Univariate factor survival analysis showed that patients with the ex-tent of necrosis < 10% of tumor area was significantly associated with prolonged overall survival compared to that of≥10% of tumor area(P = 0. 014). Cox multivariate modelling confirmed that extent of tumor necrosis was an inde-pendent prognostic variable with respect to overall survival of colon cancer patients(HR = 2. 162,95% CI = 1. 032 ~4. 531,P = 0. 041). Conclusion:Tumor necrosis is likely to play an important role in colon cancer progression. Tumor necrosis proved to be an independent prognostic factor for colon cancer patients.
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