Objective:To investigate the therapeutic effect of three chemotherapy schemes in the treatment of ad-vanced metastatic ovarian cancer.Methods:All 93 patients of advanced metastatic ovarian cancer in our hospital were selected and randomly divided into paclitaxel and cisplatin (TP),paclitaxel plus carboplatin (TC),gemcitabine and cisplatin (GP)three groups.Results:24 cases (72.73%)were effective in TP group,16 cases (53.33%)were ef-fective in TC group,21 cases (70.00%)were effective in GP group,and TP group had the highest efficiency,TC group had the lowest rate(P <0.05).15 cases (45.45%)developed bone marrow suppression in TP group,which were higher than those of 9 cases (30.00%)in TC group and 12 cases (40.00%)in GP group(P <0.001).14 ca-ses (46.67%)had digestive tract reaction in TC group,which were higher than those of 8 cases (24.24%)in TP group and 8 cases (26.67%)in GP group(P <0.001).Conclusion:TC regimen has a low therapeutic effective rate in the treatment of advanced metastatic ovarian cancer,schemes TP,GP can obtain the good clinical curative effect, improve the prognosis of patients,and have fewer side effects,which can be used as the first -line chemotherapy scheme.%目的：探讨三种化疗方案治疗晚期转移性卵巢癌的疗效。方法：选取2010年5月－2014年5月我院就诊的部分晚期转移性卵巢癌患者93例，采用随机数字法分为紫杉醇＋顺铂（TP）、紫杉醇＋卡铂（TC）、吉西他滨＋顺铂（GP）三组。观察比较不同化疗方案对患者的临床疗效及其毒副反应。结果：TP 组有效24例（72．73％），TC 组有效16例（53．33％），GP 组有效21例（70．00％）；TP 组化疗有效率最高，TC 组有效率最低，差异有统计学意义（P ＜0．05）。TP 组发生骨髓抑制共15例（45．45％），高于 TC 组的9例（30．00％）及GP 组的12例（40．00％），差异均有统计学意义（P ＜0．001）。TC 组发生消化道反应共14例（46．67％），高于TP 组的8例（24．24％）及 GP 组的8例（26．67％），差异均有统计学意义（P ＜0．001）。结论：TC 方案治疗有效率较低，TP、GP 两种方案均可获得较好的临床疗效，有效改善患者预后，且毒副反应较轻，可以作为一线化疗方案推广使用。
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