Objective: To study the clinicopathological characteristics of hihg - grade colorectal intraepithelial ne-olpasia and analyze the cause of diagnostic difference pre - and post - operations. Methods: Retrospective review of the clinicopathological featurse of 47cases of high - grade colorectal intrepithelial neoplasia diagnosed by colonoscopy biopsy,and compared with the pathological finding of surgical speciments. Results:The most quality of high -grade neolpasia located in the rectum,some was in the sigmoid and transverse colon. In the 47 cases, 12 cases still showed high - grade intraepithelial neoplasia and 35cases were diagnosed with a malignant carcinoma afer operations. Conclusion : Pathological diagnose of colorectal high - grade intraepithelial showed poor consistency pre - and post - treatment, especially in rectum. Close communication between clinicians and pathologists is essential to raise the correct diagnosis rate and choice reasonable treatment of those patients.%目的:探讨结直肠高级别上皮内瘤变的临床病理学特征及手术前后病理诊断的差异.方法:对47例内镜活检病理诊断结直肠高级别上皮内瘤的病例进行回顾性总结,分析其临床病理特点.并与术后病理结果进行对照分析.结果:结直肠上皮内瘤变好发部位以直肠最多,其次为乙状结肠和横结肠.最终确诊35例为结直肠癌,12例仍为高级别上皮内瘤变.结论:结直肠高级别上皮内瘤变术前与术后病理诊断存在较大的差异,尤其是在直肠部位.临床及病理医生应充分沟通,以提高诊断正确率及选择合理的治疗方式.
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