Objective To investigate the value of combined detection of four serum tumor markers(SCC-Ag,DcR3,RhoA and HIF-1α)in the early diagnosis of cervical cancer.Methods Serum levels of SCC-Ag,DcR3,RhoA and HIF-1αwere detected by ELISA in 60 patients with cervical cancer and 30 healthy control subjects.Results Serum levels of SCC-Ag,DcR3,RhoA and HIF-1αin cervical cancer patients were significantly higher than those in control subjects (P<0.05),and their expression levels were closely related to the TNM staging of cervical canc-er.The levels of SCC-Ag and HIF-1αin patients with lymphatic metastasis were significantly higher than those in patients without lymphatic metastasis(P<0.05).In addition,the levels of SCC-Ag in patients with cervical squamous carcinoma were significantly higher than those in pa-tients with cervical adenocarcinoma (P<0.05 ).Conclusion Combined detection of SCC Ag, DcR3,RhoA and HIF-1αcan be used as a general cervical cancer screening test,which provides a new method and idea for cervical cancer screening,diagnosis,treatment and prognosis assessment.%目的 探讨血清中4种肿瘤标志物(TM)鳞状上皮抗原(SCC-Ag)、诱骗受体3(DcR3)、Ras同源基因家族成员A(RhoA)和缺氧诱导因子(HIF)-1α联合检测对早期诊断宫颈癌的价值.方法 选取宫颈癌患者60例宫颈癌组、健康体检妇女30例(对照组)为研究对象,采用ELISA法检测并分析2组血清中SCC-Ag、DcR3、RhoA及HIF-1α的表达水平.结果 宫颈癌组4种TM水平均显著高于对照组(P<0.05),且其表达水平高低与宫颈癌的TNM分期有关.淋巴转移者SCC-Ag和HIF-1α表达水平显著高于非淋巴转移者(P<0.05);宫颈鳞癌中SCC-Ag表达水平显著高于宫颈腺癌(P<0.05).结论 联合检测SCC-Ag、DcR3、RhoA和HIF-1α可作为普查项目,为宫颈癌的筛查、诊治、评估预后提供新的方法和思路.
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