微小RNA(microRNA,miRNA)是一类由18~25个核苷酸构成的非编码RNA分子,在调控基因表达方面发挥重要作用,许多疾病的发生发展与miRNA功能失调有关,miRNA-206在许多肿瘤如胃癌、卵巢癌、黑色素瘤细胞、乳腺癌、肺癌和肝癌等组织中都有异常表达,在肿瘤细胞增殖、分化、凋亡及转移中发挥了重要影响.本文就近年来miRNA-206在肿瘤发生发展中作用的研究进展进行综述,并指出其重要的临床诊断和治疗的潜在价值.%MicroRNAs are a class of small non-coding RNAs (18-25 nucleotides)that play an important role in the regulation of gene expression.The occurrence and development of many dis-eases are associated with the miRNA dysfunction.The miRNA-206 is abnormally expressed in many tumors,such as gastric cancer,ovarian cancer,melanoma,breast cancer,lung cancer and liv-er cancer,suggesting that miRNA-206 plays an important role in the proliferation,differentiation, apoptosis and metastasis of tumor cells.This review summarizes the research progress in the role of miRNA-206 in the pathogenesis of tumors and indicates its potential value in clinical diagnosis and treatment of tumors.
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