目的：了解人体血液中某些宏微量元素等在不同年龄人群中的含量变化，以阐明其与衰老的关系。方法选择南昌市东湖、洪都及九江市沙河的部分社区为调查现场，分层随机抽取≥20岁不同年龄段的人群为调查对象，通过自构建的生理-心理-社会三维衰老度量表进行衰老度测量评分；取部分血样采用原子吸收分光光度计测量相关宏微量元素含量，超氧化物歧化酶（SOD）采用羟胺法检测。结果196名调查对象的血清中 Zn、Mn、Se、Cu／Zn、Cu／Fe 的值随年龄增大而降低，Cu 随年龄增大而增高，SOD 活性随年龄增大而下降（均 P ＜0．001）。经多元线性回归分析：Zn、Mn、Fe 和年龄的关系密切；Mn、Zn 对 SOD 活性具有保护作用；Cu、Mn、Se、Fe、Cu／Zn、Cu／Fe、SOD与现有量表总分关系密切（均 P ＜0．001）。结论补充 Zn、Mn 可能会提高血清 SOD 活性，且可能具有抗衰老的效果；将 Mn、Zn、SOD 等纳入衰老度的评价指标有积极意义。%ABSTRACT:Objective To investigate the changes in blood contents of some inorganic elements in different age groups,and to demonstrate their relationships to aging.Methods Subjects with different ages(≥20 years old)were selected from some communities of Nanchang Donghu,Nan-chang Hongdu and Jiujiang Shahe using stratified random sampling.The aging degree was evalua-ted using self-designed physiologic-mental-social aging scale.Blood contents of inorganic elements were detected using atomic absorption spectrophotometer.Superoxide dismutase(SOD)activity was measured by hydroxylamine method.Results Serum contents of Zn,Mn and Se,ratios of Cu/Zn and Cu/Fe,and activity of SOD decreased with age(all P <0.001).However,serum Cu content increased with age(all P <0.001).Multivariate linear regression analysis showed that serum con-tents of Zn,Mn and Fe were closely correlated with the age.Both Mn and Zn exerted protective effect on SOD activity.In addition,serum contents of Zn,Mn and Se,ratios of Cu/Zn and Cu/Fe, and activity of SOD were closely related to total scores of physiologic-mental-social aging scale(all P <0.001).Conclusion The supplement of Zn and Mn increases SOD activity and exerts anti-ag-ing effect.Therefore,it is of great importance to induce Mn,Zn and SOD into the system of aging evaluation.
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