近年来，磷酸腺苷依赖的蛋白激酶（AMPK、5′-AMP-activated protein kinase）在细胞自噬（autophagy）中的研究已成为热点之一。自噬是一个多步骤复杂的过程并对能量敏感，AMPK 作为能量感受器对营养敏感且在自噬的过程中发挥关键酶的作用。本文主要介绍了细胞自噬以及 AMPK 通过 mTOR（mammalian target of rapamy-cin）、p53、PI3K 3条通路影响自噬通路的过程。%In recent years,the role of AMPK in autophagy has become a research hotpot.Auto-phagy is a complex and multi-stage process,which is sensitive to energy.As an energy sensor, AMPK is sensitive to nutrition and plays a key role in autophagy.In this paper,we mainly focus on the effects of AMPK on autophagy through mTOR,p53 and PI3K pathways.
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