Objective To investigate the changes in serum C-reactive protein (CRP) in neo-nates with infectious jaundice and their clinical significance. Methods Total bilirubin(TBIL) , indirect bilirubin (IBIL) , white blood cell count (WBC) and CRP were determinated in 28 neonates with infectious jaundice (observation group) and 50 neonates with physiological jaundice (control group) before and after treatment. Results were compared between the two groups. Results Before treatment, the levels of TBIL,IBIL, WBC and CRP in observation group were significantly higher than those in control group (P<0. 01). There were statistically significant differences in these indexes before and after treatment (P<0. 01);Serum CRP was positively correlated with WBC by excluding the effects of bilirubin (partial correlation coefficient = 0. 820 7,P<0. 01). Conclusion The CRP can be used as an indicator of infectious jaundice in neonates,and dynamic observation of CRP levels will help determine the disease evolution and therapeutic efficacy.%目的 探讨血清C反应蛋白(CRP)在新生儿感染性黄疸疾病中的变化及临床意义.方法 测定观察组(28例感染性黄疸新生儿)及对照组(50例生理性黄疸新生儿)治疗前后的总胆红素(TBIL)、间接胆红素(IBIL)、WBC、CRP指标,并对2组所测结果进行分析.结果 观察组治疗前TBIL、IBIL、WBC、CRP指标均高于对照组,差异有统计学意义(P＜0.01)；观察组治疗前后比较,差异亦有统计学意义(P＜0.01)；排除胆红素的影响,血清CRP与WBC呈正相关(偏相关系数为0.820 7,P＜0.01).结论 CRP可作为早期诊断新生儿感染性黄疸的指标之一,动态观察其水平变化有助于判定病情的演变及治疗效果.
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