To assess the value of levels of CA19-9 and CEA in serum and ascites in the diagnosis of malignant tumor in digestive system. Methods: The levels of CA19-9 and CEA in serum were detected rnby RIMA and RIA, respectively, in healthy adults (n= 126) and in patients with malignant tumor of digestive system (n=192) before and after operation. The difference of levels of CA19-9 and CEA between the patients with malignant ascites (n=20) and benign ascites (n=28) was observed. The positive rate of CA19-9, CEA, combined CA19-9 and CEA in serum were compared. Results: The levels of CA19-9 and CEA in serum in patients with malignant tumor of digestive system were higher than those in the healthy rngroup (P<0.01), and were significantly decreased after operation (P<0. 01). The positive rate of combined CA19-9 and CEA was significantly higher than that of individual CA19-9 or CEA (P<0. 05). The levels of CA19-9 and CEA in serum and ascites were higher in patients with malignant ascites than in parntients with benign ascites (P<0. 01). Conclusions: Combined detection of levels of CA19-9 and CEA in rnserum and ascites might be useful in diagnosis of malignant tumor of digestive system, in observation ofthe therapy effect and in identification of tumor.%目的：评价血清和腹水中CAl9-9、CEA含量变化对消化系统恶性肿瘤的诊断价值。方法：CAl9-9采用免疫放射法(RIMA)、CEA采用放射免疫法(RIA)，检测192例消化系统恶性肿瘤手术前、后及126例正常人血清CAl9-9、CEA的含量；并观察20例癌性腹水及28例良性腹水CAl9-9、CEA的含量与变化。且对血清CAl9-9、CEA单项与联检阳性率进行比较。结果：所测各种恶性肿瘤病人血清CAl9-9、CEA的含量均显著高于正常对照组(P<0.01)，手术后患者血清CAl9-9、CEA的水平显著低于手术前(P<0.01)；术前、术后比较阳性率有显著性差异(P<0.01)，且联检较单检阳性率有明显提高(P<0.05)；癌性腹水患者血清、腹水中CAl9-9、CEA水平明显高于良性腹水患者(P<0.01)。结论：联合检测血清和腹水中CAl9-9、CEA在消化系统恶性肿瘤的辅助诊断、疗效观察及良恶性腹水的鉴别中均有一定的临床应用价值。
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