Objective To explore the efficacy of dexmedetomidine in treatment of insomnia and the effect of the method on hyperarousal. Methods A total 22 patients with insomnia were enrolled in this study. All patients received sleep monitoring, blood serum cortisol measurement, rating scales evaluation and system check before and after they received the operation of dexmedetomidine induce sleep balancing. Results Comparing to preoperative measures, the patients' sleep latency period reduced, total sleep times extended, sleep efficiency raised up, and blood serum cortisol decreased after the operation of dexmedetomidine induce sleep balancing (P < 0. 05). However, the number and total time of wakening did not decrease (P > 0.05). Conclusions The operation of dexmedetomidine induced sleep balancing may significant reduce the sleep latency period, increase total sleep times, improve sleep efficiency, reduce blood serum cortisol, and inhibit the hyperarousal, but does not improve the sleep sustaining state.%目的 探讨右美托咪定治疗失眠症的疗效以及该治疗方法对失眠症过度觉醒的影响.方法 对本科室22例失眠症患者行睡眠监测、血清皮质醇检测、相关量表评估及各系统检查,并行盐酸右美托咪定诱导睡眠平衡术,术后复查睡眠监测、血清皮质醇进行疗效评估.结果 行盐酸右美托咪定诱导睡眠平衡术后,失眠症患者较术前睡眠潜伏期缩短(P＜0.05),睡眠总时间延长(P＜0.05),睡眠效率增高(P＜0.05),觉醒次数及入睡后清醒时间无明显减少(P＞0.05),清晨8:00血皮质醇降低(P＜0.05).结论 盐酸右美托咪定诱导睡眠平衡术可缩短失眠症患者的睡眠潜伏期,延长睡眠总时间,改善睡眠效率,但对睡眠维持状态无明显改善,并可降低血皮质醇抑制过度觉醒状态.
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