Objective To investigate the association between Pulse Pressure ( PP) , Pulse Pressure Index (PPI) and Early Renal Injury in patients with hypertension complicated with type 2 diabetes mellitus. Methods 160 cases with essential hypertension were divided into the hypertension complicated with diabetes group (Complication group, re =78) and hypertension control group based on complication with or without diabetes ( Control group, n = 82 ) . The complication group were divided into different groups according to the levels of ambulatory PP(APP) ( <60mmHg or≥60mm Hg) and PPI ( <0. 5 or≥0. 5). Urinary - MAU,β2 - 2MG and 24h ambulatory blood pressure levels were detected. Results PP, PPI, MAU and β2 - MG in complication group were significantly higher than those in control group ( P < 0. 05 ) ; MAU and β2 - MG in 24hPP ≥ 60mmHg group were significantly higher than those in 24hPP <60mmhg group (P <0. 05 ) ; MAU and β2 -MG in PPI ≥0. 5 group were significantly higher than those in PPI < 0. 5 group ( P < 0. 05 ) ; The PP and PPI was positive correlated to the MAU and β2 -2MG . Conclusion PP and PPI can sensitively predict the early renal impairment.%目的 探讨脉压、脉压指数与高血压合并2型糖尿病患者早期肾损害的相关性.方法 160例原发性高血压患者根据是否合并2型糖尿病分为:单纯高血压组(EH组)82例,高血压合并2型糖尿病组(EH+DM组)78例;根据24h动态脉压(24hPP)水平将EH+DM患者分为:24hPP＜60mmHg组(40例) 和24hPP≥60mmHg组(38例);根据24h脉压指数(PPI)将EH+DM患者分为 PPI＜0.5 组(36例)和 PPI≥0.5组(42例).测量所有研究对象24h动态血压、尿微量白蛋白.比较各组指标,分析PP、PPI与MAU,尿β2-MG之间的关系.结果 EH+DM组 24hPP、PPI、MAU,尿β2-MG明显高于EH组(P＜0.05);24hPP≥60mmHg组MAU、β2-MG水平明显高于24hPP＜60mmHg组(P＜0.05);PPI≥0.5组MAU,尿β2-MG水平明显高于PPI＜0.5 组(P＜0.05);PP、PPI与MAU、尿β2-MG成正相关.结论 PP、PPI是预测高血压合并2型糖尿病早期肾损害的良好指标.
展开▼
