Objective:To assess the correlation of high mobility group box 1 (HMGB-1) with Organoleptic rating(OR),dental plaque index(PLI) and halitosis with chronic periodontitis.Methods:Serum samples from 20 halitosis patients,20 chronic periodontitis patients with oral malodor and 8 healthy controls were collected.The level of HMGB-1 in the serum was detected by ELISA.The OR and PLI were estimated by organoleptic method and periodontal examination respectively.The data were analyzed with SPSS 17.0.Results:The levels of HMGB1 in the serum from 2 groups of patients was significantly higher than that of the controls(P ＜0.01).The level of HMGB-1 in the patients of halitosis with chronic periodontitis was significantly higher than that of the halitosis patients(P ＜ 0.01).There was no statistical difference of OR between the 2 groups of patients(P ＞ 0.05).The PLI of the chronic periodontitis patients with oral malodor was significantly higher than that of halitosis patients (P ＜ 0.01).The correlation of HMGB1 with OR and PLI of 2 groups of patients were positively correlated(P ＜ 0.05 and 0.01 respectively),the OR of halitosis patients showed no relevant(P ＞0.05).Conclusion:HMGB-1 may be one of the important factors that result in chronic periodontal inflammation and stubborn bad breath.%目的:探讨高迁移率族蛋白1(HMGB-1)与口臭和口臭伴慢性牙周炎患者口臭值(OR)和牙菌斑指数(PLI)的相关性.方法:采集口臭、口臭伴慢性牙周炎患者各20例和8例健康志愿者的外周血.ELISA测定血清中HMGB-1水平.鼻闻法测患者OR,检查记录PLI.SPSS 17.0分析数据.结果:2组患者外周血HMGB-1均显著高于正常人(P＜0.05和0.01),且口臭伴慢性牙周炎患者显著高于口臭患者(P＜0.01);2组患者OR无明显差异(P＞0.05),但口臭伴慢性牙周炎患者PLI却显著高于口臭患者(P＜0.01);2组患者OR、PLI和HMGB-1之间的关系,除口臭患者OR不相关外(P＞0.05),其余均呈明显正相关(P＜0.05和0.01).结论:HMGB-1可能是导致牙周炎症慢性化和顽固性口臭的重要因素之一.
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